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Chemical Constituents from Garcinia maingayi and Garcinia parvifolia (Guttiferae) and Their Biological Activities

G.C.L. Ee and Y.L. Cheow

Pertanika Journal of Science & Technology, Volume 15, Issue 2, July 2007

Keywords: Garcinia maingayi, Garcinia parvifolia, 1,3,7-trihydroxy-2-(3-methylbut-2-enyl)xanthone, isoxanthochymol, 3,4-dihydroxy-methylbenzoate, cowanin, rubraxanthone, triacetate rubraxanthone

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Abstract

Detail chemical studies on Garcinia maingayi have yielded one xanthone, 1,3,7-trihydroxy- 2-(3-methylbut-2-enyl)-xanthone, one benzophenone, isoxanthochymol, one benzoic acid derivative 3,4-dihydroxy-methylbenzoate and two triterpenoids, stigmasterol and sitosterol. Meanwhile, investigations on Garcinia parvifolia have afforded one triterpenoid, ?-amyrin and two xanthones, cowanin and rubraxanthone. Their structures were derived based on spectroscopic evidence, mainly ID and 2D NMR spectroscopy. Acetylation reaction was carried out on rubraxanthone to yield triacetate rubraxanthone. It was found that the pure rubraxanthone was strongly active against the larvae of Aedes aegypti with LC50 value of 15.49 μg/ ml and HL-60 cells line with an IC50 value of 7.5 μg/ ml.

ISSN 0128-7680

e-ISSN 2231-8526

Article ID

JST-0011-2007